LYMPHOID NEOPLASIA Deregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications
نویسندگان
چکیده
1Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie (UPMC) Paris VI, Inserm, Paris, France; 2CNRS UMR 3348, Institut Curie, Université Paris Sud-11, Orsay, France; 3Institut Cochin, Université Paris Descartes, CNRS, Paris, France, 4Inserm, Paris, France; 5Hôpital Pitié-Salpêtrière, Service d’Hématologie Biologique, Paris, France; and 6CDR des Cordeliers, UPMC Paris VI, Inserm, Paris, France
منابع مشابه
Deregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications.
Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of mature neoplastic B cells that are resistant to apoptosis. Aiolos, a member of the Ikaros family of zinc-finger transcription factors, plays an important role in the control of mature B lymphocyte differentiation and maturation. In this study, we showed that Aiolos expression is up-regulated in B-CLL cells. This ove...
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متن کاملThe Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia.
The Aiolos transcription factor, member of the Ikaros family of zinc finger proteins, plays an important role in the control of mature B lymphocyte differentiation and proliferation, and its function appears to be modulated through alternative splicing. To assess Aiolos isoform role in humans' pathologies, we studied Aiolos variant distribution and expression in mature B lymphoproliferative dis...
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